ea0050p003 | Adrenal and Steroids | SFEBES2017
Fudulu Daniel
, Horn George
, Hazell Georgina
, Angelini Gianni
, Lightman Stafford
, Spiga Francesca
The hypothalamic-pituitary-adrenal axis is the primary neuroendocrine system activated to establish homeostasis during the stress of critical illness and surgery. However, such critical states also trigger a systemic inflammatory activation that usually precedes the release of adrenocorticotrophic hormone (ACTH) and cortisol. Systemically or locally induced inflammation of the adrenal gland had been described during critical illness. This facilitates...